Enriched Environment and White Matter in Aging Brain
نویسندگان
چکیده
منابع مشابه
White matter hyperintensities and normal-appearing white matter integrity in the aging brain
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in brain magnetic resonance imaging of older individuals and contribute to cognitive and functional decline. It is unknown how WMH form, although white matter degeneration is characterized pathologically by demyelination, axonal loss, and rarefaction, often attributed to ischemia. Changes within normal-appearin...
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M. E. Bastin1, J. D. Clayden2, J. P. Piatkowski3, A. J. Storkey4, L. J. Brown5, and A. M. MacLullich5 Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Edinburgh, United Kingdom, Institute of Child Health, University College London, London, United Kingdom, Neuroinformatics Doctoral Training Centre, School of Informatics, University of Edinburgh, Edinburgh, United Kin...
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BACKGROUND The earliest white matter changes in Huntington's disease are seen before disease onset in the premanifest stage around the striatum, within the corpus callosum, and in posterior white matter tracts. While experimental evidence suggests that these changes may be related to abnormal gene transcription, we lack an understanding of the biological processes driving this regional vulnerab...
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Cerebral white matter hyperintensities (WMH) reflect accumulating white matter damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment and WMH. We studied community-dwelling older people all born in 1936, in whom IQ had been assessed at age 11 years. We assessed medical histories, current cognitive ability and ...
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BACKGROUND AND PURPOSE Most previous studies addressed the cognitive impact of lacunar infarcts using radiologic correlations that are known to correlate poorly with neuropathological data. Moreover, absence of systematic bilateral assessment of vascular lesions and masking effects of Alzheimer disease pathology and macrovascular lesions may explain discrepancies among previous reports. To defi...
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ژورنال
عنوان ژورنال: The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
سال: 2012
ISSN: 1932-8486
DOI: 10.1002/ar.22526